Harlow Laboratory

Harlow Laboratory Publications

2008
2007
2005
2004
2002
2001
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1999
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2008

Grueneberg DA, Degot S, Pearlberg J, Li W, Davies JE, Baldwin A, Endege W, Doench J, Sawyer J, Hu Y, Boyce F, Xian J, Munger K, and Harlow E. "Kinase Requirements in Human Cells: I. Comparing Kinases Requirements Across Various Cell Types.” PNAS.2008 Oct 28;105(43):16472-7. Epub 2008 Oct 23. PMID: 18948591

Baldwin S, Li W, Grace W, Pearlberg J, Harlow E, Münger K and Grueneberg DA. "Kinase Requirements in Human Cells: II. Genetic Interaction Screens Identify Kinase Requirements Following HPV16 E7 Expression in Cancer Cells.” PNAS. 2008 Oct 28;105(43):16478-83. Epub 2008 Oct 23. PMID: 18948598

Bommi-Reddy A, Almeciga I, Sawyer J, Geisen C, Li W, Harlow E, Kaelin Jr. WG, and Grueneberg DA. "Kinase Requirements in Human Cells: III. Altered Kinase Requirements in VHL-/- Renal Carcinoma Cells Detected in a Pilot Synthetic Lethal Screen.” PNAS.2008 Oct 28;105(43):16484-9. Epub 2008 Oct 23. PMID: 18948595

Grueneberg DA, Li W, Davies JE, Sawyer J, Pearlberg J, and Harlow E. "Kinase Requirements in Human Cells: IV. Differential Kinase Requirements in Cervical and Renal Human Tumor Cell Lines.” PNAS 2008 Oct 28;105(43):16490-5. Epub 2008 Oct 23. PMID: 18948597

2007

Hu Y, Rolfs A, Bhullar B, Murthy TV, Zhu C, Berger MF, Camargo AA, Kelley F, McCarron S, Jepson D, Richardson A, Raphael J, Moreira D, Taycher E, Zuo D, Mohr S, Kane MF, Williamson J, Simpson A, Bulyk ML, Harlow E, Marsischky G, Kolodner RD, LaBaer J.“Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.” Genome Res. 2007 Apr;17(4):536-43. Epub 2007 Feb 23. PMID: 17322287

2005

Pearlberg J, Degot S, Endege W, Park J, Davies J, Gelfand E, Sawyer J, Conery A, Doench J, Li W, Gonzalez L, Boyce FM, Brizuela L, Labaer J, Grueneberg D, Harlow E.“Screens using RNAi and cDNA expression as surrogates for genetics in mammalian tissue culture cells.Cold Spring Harb Symp Quant Biol. 2005;70:449-59.” PMID: 16869783

Park J, Hu Y, Murthy TV, Vannberg F, Shen B, Rolfs A, Hutti JE, Cantley LC, Labaer J, Harlow E, Brizuela L.“Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation.” Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8114-9. Epub 2005 May 31. PMID: 15928075

2004

Johnson BR, Nitta RT, Frock RL, Mounkes L, Barbie DA, Stewart CL, Harlow E, Kennedy BK. “A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.” Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9677-82. Epub 2004 Jun 21. PMID: 15210943

Barbie DA, Kudlow BA, Frock R, Zhao J, Johnson BR, Dyson N, Harlow E, Kennedy BK.“Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit.” Mol Cell Biol. 2004 Jan;24(2):595-607. PMID: 14701733

2002

Kohn MJ, Bronson RT, Harlow E, Dyson NJ, Yamasaki L. “Dp1 is required for extra-embryonic development.” Development. 2003 Apr;130(7):1295-305. PMID: 12588846

Classon M, Harlow E. “The retinoblastoma tumour suppressor in development and cancer.” Nat Rev Cancer. 2002 Dec;2(12):910-7. Review. PMID: 12459729

Fingar DC, Salama S, Tsou C, Harlow E, Blenis J. “Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E.” Genes Dev. 2002 Jun 15;16(12):1472-87. PMID: 12080086

Braun P, Hu Y, Shen B, Halleck A, Koundinya M, Harlow E, LaBaer J. “Proteome-scale purification of human proteins from bacteria.” Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2654-9. PMID: 11880620

2001

Lee SB, Kim SH, Bell DW, Wahrer DC, Schiripo TA, Jorczak MM, Sgroi DC, Garber JE, Li FP, Nichols KE, Varley JM, Godwin AK, Shannon KM, Harlow E, Haber DA. “Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome.” Cancer Res. 2001 Nov 15;61(22):8062-7. PMID: 11719428

Kennedy BK, Liu OW, Dick FA, Dyson N, Harlow E, Vidal M. “Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft.” Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8720-5. Epub 2001 Jul 10. PMID: 11447271

Lai A, Kennedy BK, Barbie DA, Bertos NR, Yang XJ, Theberge MC, Tsai SC, Seto E, Zhang Y, Kuzmichev A, Lane WS, Reinberg D, Harlow E, Branton PE. “RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest.” Mol Cell Biol. 2001 Apr;21(8):2918-32.” PMID: 11283269

Stevenson LF, Kennedy BK, Harlow E. “A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes.” Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3946-51. PMID: 11274415

2000

Mihich E, Harlow E. “Twelfth annual Pezcoller symposium: signaling cross-talks in cancer cells.” Cancer Res. 2000 Dec 15;60(24):7177-83. PMID: 11156428

Kennedy BK, Barbie DA, Classon M, Dyson N, Harlow E. “Nuclear organization of DNA replication in primary mammalian cells. ” Genes Dev. 2000 Nov 15;14(22):2855-68. PMID: 11090133

Classon M, Kennedy BK, Mulloy R, Harlow E. “Opposing roles of pRB and p107 in adipocyte differentiation. ” Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10826-31. PMID: 10995476

Classon M, Salama S, Gorka C, Mulloy R, Braun P, Harlow E. “Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control.” Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10820-5. PMID: 10995475

Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E. “NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.” Genes Dev. 2000 Sep 15;14(18):2283-97. PMID: 10995386

1999

McCaffrey J, Yamasaki L, Dyson NJ, Harlow E, Griep AE. “Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1.” Mol Cell Biol. 1999 Sep;19(9):6458-68. PMID: 10454591

Lukas ER, Bartley SM, Graveel CR, Diaz ZM, Dyson N, Harlow E, Yamasaki L, Farnham PJ. “No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice ” Mol Carcinog. 1999 Aug;25(4):295-303. PMID: 10449036

1998

Pan H, Yin C, Dyson NJ, Harlow E, Yamasaki L, Van Dyke T. “Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors.” Mol Cell. 1998 Sep;2(3):283-92. PMID: 9774967

Harrington EA, Bruce JL, Harlow E, Dyson N. “pRB plays an essential role in cell cycle arrest induced by DNA damage.” Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11945-50. PMID: 9751770

Schulman BA, Lindstrom DL, Harlow E. “Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A.” Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10453-8. PMID: 9724724

Yamasaki L, Bronson R, Williams BO, Dyson NJ, Harlow E, Jacks T. “Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice.” Nat Genet. 1998 Apr;18(4):360-4. PMID: 9537419

Zhao J, Dynlacht B, Imai T, Hori T, Harlow E. “Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry.” Genes Dev. 1998 Feb 15;12(4):456-61. PMID: 9472014

1997

Haber D, Harlow E. “Tumour-suppressor genes: evolving definitions in the genomic age.” Nat Genet. 1997 Aug;16(4):320-2. PMID: 9241260

Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L. “Specific regulation of E2F family members by cyclin-dependent kinases.” Mol Cell Biol. 1997 Jul;17(7):3867-75. PMID: 9199321

LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A, Harlow E. “New functional activities for the p21 family of CDK inhibitors.” Genes Dev. 1997 Apr 1;11(7):847-62. PMID: 9106657

Goillot E, Raingeaud J, Ranger A, Tepper RI, Davis RJ, Harlow E, Sanchez I. “Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway.” Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3302-7. PMID: 9096388

Zarkowska T, U S, Harlow E, Mittnacht S. “Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs.” Oncogene. 1997 Jan 16;14(2):249-54. PMID: 9010227

Dynlacht BD, Ngwu C, Winston J, Swindell EC, Elledge SJ, Harlow E, Harper JW. “Purification and analysis of CIP/KIP proteins.” Methods Enzymol. 1997;283:230-44. PMID: 9251023

1996

Vidal M, Braun P, Chen E, Boeke JD, Harlow E. “Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system.” Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10321-6. PMID: 8816798

Vidal M, Brachmann RK, Fattaey A, Harlow E, Boeke JD. “Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.” Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10315-20. PMID: 8816797

Harlow E. “A research shortcut from a common cold virus to human cancer.” Cancer. 1996 Aug 1;78(3):558-65. PMID: 8697405

Magae J, Wu CL, Illenye S, Harlow E, Heintz NH. “Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members.” J Cell Sci. 1996 Jul;109 ( Pt 7):1717-26. PMID: 8832394

Zukerberg LR, Benedict WF, Arnold A, Dyson N, Harlow E, Harris NL. “Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1.” Blood. 1996 Jul 1;88(1):268-76. PMID: 8704183

Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T. “Shared role of the pRB-related p130 and p107 proteins in limb development.” Genes Dev. 1996 Jul 1;10(13):1633-44. PMID: 8682294

Lee MH, Williams BO, Mulligan G, Mukai S, Bronson RT, Dyson N, Harlow E, Jacks T. “Targeted disruption of p107: functional overlap between p107 and Rb.” Genes Dev. 1996 Jul 1;10(13):1621-32. PMID: 8682293

Wu CL, Classon M, Dyson N, Harlow E. “Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1.” Mol Cell Biol. 1996 Jul;16(7):3698-706. PMID: 8668186

Yamasaki L, Jacks T, Bronson R, Goillot E, Harlow E, Dyson NJ. “Tumor induction and tissue atrophy in mice lacking E2F-1.” Cell. 1996 May 17;85(4):537-48. PMID: 8653789

Enders GH, Koh J, Missero C, Rustgi AK, Harlow E. “p16 inhibition of transformed and primary squamous epithelial cells.” Oncogene. 1996 Mar 21;12(6):1239-45. PMID: 8649826

Harlow E. 1996. "A research shortcut from a common cold virus to human cancer." in Accomplishments in Cancer Research 1995. ed. J. G. Fortner and P. A. Sharp. Lippincott-Raven. pp. 57-68.

1995

Zhu L, Harlow E, Dynlacht BD. “p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.” Genes Dev. 1995 Jul 15;9(14):1740-52. PMID: 7622038

Koh J, Enders GH, Dynlacht BD, Harlow E. “Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition.” Nature. 1995 Jun 8;375(6531):506-10. PMID: 7777061

Zhu L, Enders G, Lees JA, Beijersbergen RL, Bernards R, Harlow E. “The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.” EMBO J. 1995 May 1;14(9):1904-13. PMID: 7743997

Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA. “In vivo association of E2F and DP family proteins.” Mol Cell Biol. 1995 May;15(5):2536-46. PMID: 7739537

Wade M, Blake MC, Jambou RC, Helin K, Harlow E, Azizkhan JC. “An inverted repeat motif stabilizes binding of E2F and enhances transcription of the dihydrofolate reductase gene.” J Biol Chem. 1995 Apr 28;270(17):9783-91. PMID: 7730357

1994

Saito M, Helin K, Valentine MB, Griffith BB, Willman CL, Harlow E, Look AT. “Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line.” Genomics. 1995 Jan 1;25(1):130-8. PMID: 7774910

Tsai LH, Delalle I, Caviness VS Jr, Chae T, Harlow E. “p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.” Nature. 1994 Sep 29;371(6496):419-23. PMID: 8090221

Helin K, Harlow E. “Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein.” J Virol. 1994 Aug;68(8):5027-35. PMID: 8035503

Dynlacht BD, Flores O, Lees JA, Harlow E. “Differential regulation of E2F transactivation by cyclin/cdk2 complexes.” Genes Dev. 1994 Aug 1;8(15):1772-86. PMID: 7958856

Meyerson M, Harlow E. “Identification of G1 kinase activity for cdk6, a novel cyclin D partner.” Mol Cell Biol. 1994 Mar;14(3):2077-86. PMID: 8114739

Mittnacht S, Lees JA, Desai D, Harlow E, Morgan DO, Weinberg RA. “Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation.” EMBO J. 1994 Jan 1;13(1):118-27. PMID: 8306955

Zhu L, Enders GH, Wu CL, Starz MA, Moberg KH, Lees JA, Dyson N, Harlow E. “Growth suppression by members of the retinoblastoma protein family.” Cold Spring Harb Symp Quant Biol. 1994;59:75-84. Review. PMID: 7587134

1993

van den Heuvel S, Harlow E. “Distinct roles for cyclin-dependent kinases in cell cycle control.” Science. 1993 Dec 24;262(5142):2050-4. PMID: 8266103

Tsai LH, Takahashi T, Caviness VS Jr, Harlow E. “Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.” Development. 1993 Dec;119(4):1029-40. PMID: 8306873

Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K. “The retinoblastoma protein binds to a family of E2F transcription factors.” Mol Cell Biol. 1993 Dec;13(12):7813-25. PMID: 8246996

Fattaey AR, Harlow E, Helin K. “Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.” Mol Cell Biol. 1993 Dec;13(12):7267-77. PMID: 8246949

Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, Hanobik MG, Haskell KM, Oliff A, Defeo-Jones D, et al. “Characterization of the retinoblastoma binding proteins RBP1 and RBP2.” Oncogene. 1993 Nov;8(11):3149-56. PMID: 8414517

Helin K, Harlow E, Fattaey A. “Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.” Mol Cell Biol. 1993 Oct;13(10):6501-8. PMID: 8413249

Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E. “Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.” Genes Dev. 1993 Oct;7(10):1850-61. PMID: 8405995

Zhu L, van den Heuvel S, Helin K, Fattaey A, Ewen M, Livingston D, Dyson N, Harlow E. “Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.” Genes Dev. 1993 Jul;7(7A):1111-25. PMID: 8319904

Fattaey A, Helin K, Harlow E. “Transcriptional inhibition by the retinoblastoma protein.” Philos Trans R Soc Lond B Biol Sci. 1993 Jun 29;340(1293):333-6. PMID: 8103936

Tsai LH, Lees E, Faha B, Harlow E, Riabowol K. “The cdk2 kinase is required for the G1-to-S transition in mammalian cells.” Oncogene. 1993 Jun;8(6):1593-602. PMID: 8502482

Faha B, Harlow E, Lees E. “The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2.” J Virol. 1993 May;67(5):2456-65. PMID: 8386263

Lees EM, Harlow E. “Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase.” Mol Cell Biol. 1993 Feb;13(2):1194-201. PMID: 8423786

1992

Dyson N, Guida P, Münger K, Harlow E. “Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins.” J Virol. 1992 Dec;66(12):6893-902. PMID: 1331501

Lees E, Faha B, Dulic V, Reed SI, Harlow E. “Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.” Genes Dev. 1992 Oct;6(10):1874-85. PMID: 1398067

Harlow E. “Retinoblastoma. For our eyes only.” Nature. 1992 Sep 24;359(6393):270-1. No abstract available. PMID: 1406928

Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH. “A family of human cdc2-related protein kinases.” EMBO J. 1992 Aug;11(8):2909-17. PMID: 1639063

Helin K, Lees JA, Vidal M, Dyson N, Harlow E, Fattaey A. “A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F.” Cell. 1992 Jul 24;70(2):337-50. PMID: 1638634

Dyson N, Guida P, McCall C, Harlow E. “Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.” J Virol. 1992 Jul;66(7):4606-11. PMID: 1534854

Harlow E. “Eleventh annual Sapporo Cancer Seminar. Connecting the dots: assembling the pathways that control cell division.” Cancer Res. 1992 Apr 15;52(8):2362-6. No abstract available. PMID: 1559240

Hu QJ, Lees JA, Buchkovich KJ, Harlow E.“The retinoblastoma protein physically associates with the human cdc2 kinase.” Mol Cell Biol. 1992 Mar;12(3):971-80. PMID: 1545827

Cao L, Faha B, Dembski M, Tsai LH, Harlow E, Dyson N. “Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.” Nature. 1992 Jan 9;355(6356):176-9. PMID: 1530885

Faha B, Ewen ME, Tsai LH, Livingston DM, Harlow E. “Interaction between human cyclin A and adenovirus E1A-associated p107 protein.” Science. 1992 Jan 3;255(5040):87-90. PMID: 1532458

Ewen ME, Faha B, Harlow E, Livingston DM. “Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins.” Science. 1992 Jan 3;255(5040):85-7. PMID: 1532457

Dyson N, Harlow E. “Adenovirus E1A targets key regulators of cell proliferation.” Cancer Surv. 1992;12:161-95. Review. PMID: 1353412

Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E. “The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.” EMBO J. 1991 Dec;10(13):4279-90. PMID: 1756735

Dyson N, and E Harlow. 1992. “Adenovirus E1A targets key regulators of cell proliferation.” in Cancer Surveys, Volume 12, Tumor Suppressor Genes, the Cell Cycle, and Cancer, A. Levine, ed. Cold Spring Harbor Laboratory Press, pp. 161-196.

Meyerson M, Faha B, Harlow E, and L-H Tsai. 1992. in The Cell Cycle, Cold Spring Harbor Symposium on Quantitation Biology. 56. D. Beach, B. Stillman, and J. Watson, eds. Cold Spring Harbor Laboratory Press, pp. 177-186.

1991

Herrmann CH, Su LK, Harlow E. “Adenovirus E1A is associated with a serine/threonine protein kinase.” J Virol. 1991 Nov;65(11):5848-59. PMID: 1833561

Hu QJ, Bautista C, Edwards GM, Defeo-Jones D, Jones RE, Harlow E. “Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides. ” Mol Cell Biol. 1991 Nov;11(11):5792-9. PMID: 1717832

Giordano A, Lee JH, Scheppler JA, Herrmann C, Harlow E, Deuschle U, Beach D, Franza BR Jr. “Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A.” Science. 1991 Sep 13;253(5025):1271-5. PMID: 1653969

Tsai LH, Harlow E, Meyerson M. “Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase.” Nature. 1991 Sep 12;353(6340):174-7. PMID: 1653904

Larose A, Dyson N, Sullivan M, Harlow E, Bastin M. “Polyomavirus large T mutants affected in retinoblastoma protein binding are defective in immortalization.” J Virol. 1991 May;65(5):2308-13. PMID: 2016761

Meyerson M, Faha B, Su LK, Harlow E, Tsai LH. “The cyclin-dependent kinase family.” Cold Spring Harb Symp Quant Biol. 1991;56:177-86. PMID: 1840251

Harlow E. 1991. “Links between DNA tumor virus transformation and cell cycle control.” in Recent Advances in Cancer Research 1990. General Motors Cancer Research Foundation, Lippincott, Philadelphia. pp. 204-212.

1990

Lee CC, Craigen WJ, Muzny DM, Harlow E, Caskey CT. “Cloning and expression of a mammalian peptide chain release factor with sequence similarity to tryptophanyl-tRNA synthetases.” Proc Natl Acad Sci U S A. 1990 May;87(9):3508-12. PMID: 2185472

Hu QJ, Dyson N, Harlow E. “The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.” EMBO J. 1990 Apr;9(4):1147-55. PMID: 2138977

Dyson N, Bernards R, Friend SH, Gooding LR, Hassell JA, Major EO, Pipas JM, Vandyke T, Harlow E. “Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.” J Virol. 1990 Mar;64(3):1353-6. PMID: 2154613

Buchkovich K, Dyson N, Whyte P, Harlow E. “Cellular proteins that are targets for transformation by DNA tumour viruses.” Ciba Found Symp. 1990;150:262-71; discussion 271-8. Review. PMID: 2142644

Buchkovich K, Dyson N, Whyte P, and E Harlow. 1990. “Cellular proteins that are targets for transformation by DNA tumour viruses.” in Proto-Oncogenes in Cell Development, Ciba Foundation Symposium No. 150, G. Bock and J. Marsh, ed., John Wiley and Sons, New York. pp. 262-270.

Dyson N, Buchkovich K, Whyte P, and E Harlow. 1990. “Cellular proteins that are targeted by DNA tumor viruses for transformation.” in Genetic Basis for Carcinogenesis, Tumor Suppressor Genes and Oncogenes. Proceedings from the 20th International Symposium of the Princess Takamatsu Cancer Research Fund. A. Knudson, E. 6 Stanbridge, T. Sugimura, M. Terada, S. Watanabe, eds. Japan Scientific Societies Press, Tokyo. pp. 191-198.

1989

Münger K, Werness BA, Dyson N, Phelps WC, Harlow E, Howley PM. “Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.” EMBO J. 1989 Dec 20;8(13):4099-105. PMID: 2556261

Buchkovich K, Duffy LA, Harlow E. “The retinoblastoma protein is phosphorylated during specific phases of the cell cycle.” Cell. 1989 Sep 22;58(6):1097-105. PMID: 2673543

Giordano A, Whyte P, Harlow E, Franza BR Jr, Beach D, Draetta G. “A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells.” Cell. 1989 Sep 8;58(5):981-90. PMID: 2570639

Dyson N, Buchkovich K, Whyte P, Harlow E. “The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus.” Cell. 1989 Jul 28;58(2):249-55. PMID: 2546678

Dyson N, Howley PM, Münger K, Harlow E. “The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product.” Science. 1989 Feb 17;243(4893):934-7. PMID: 2537532

Horowitz JM, Yandell DW, Park SH, Canning S, Whyte P, Buchkovich K, Harlow E, Weinberg RA, Dryja TP. “Point mutational inactivation of the retinoblastoma antioncogene.” Science. 1989 Feb 17;243(4893):937-40. PMID: 2521957

Whyte P, Williamson NM, Harlow E. “Cellular targets for transformation by the adenovirus E1A proteins.” Cell. 1989 Jan 13;56(1):67-75. PMID: 2521301

Dyson N, Buchkovich K, Whyte P, Harlow E. “Cellular proteins that are targetted by DNA tumor viruses for transformation.” Princess Takamatsu Symp. 1989;20:191-8. Review. PMID: 2488232

Dyson N, Buchkovich K, Whyte P, and E Harlow. 1989. “Proteins that are cellular targets for transformation by DNA tumor viruses.” in Current Communications in Molecular Biology, Recessive Oncogenes and Tumor Suppression, E. Stanbridge, W. Cavenee, and N. Hastie, eds. Cold Spring Harbor Laboratory Press, pp. 133-140.

Buchkovich K, Dyson N, Whyte P, and E Harlow. 1989. “Cellular proteins implicated in transformation by adenovirus and other DNA tumor viruses.” in Common mechanisms of transformation by small DNA tumor viruses, L. Villereal, ed. American Society for Microbiology Press, pp. 51-63.

1988

Whyte P, Buchkovich KJ, Horowitz JM, Friend SH, Raybuck M, Weinberg RA, Harlow E. “Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product.” Nature. 1988 Jul 14;334(6178):124-9. PMID: 2968522

Whyte P, Ruley HE, Harlow E.“Two regions of the adenovirus early region 1A proteins are required for transformation.” J Virol. 1988 Jan;62(1):257-65. PMID: 2960834

Horowitz JM, Friend SH, Weinberg RA, Whyte P, Buchkovich K, Harlow E. “Anti-oncogenes and the negative regulation of cell growth.” Cold Spring Harb Symp Quant Biol. 1988;53 Pt 2:843-7. PMID: 2908198

Buchkovich K, Whyte P, Horowitz JM, Friend SH, Raybuck M, Williamson N, Weinberg RA, and E Harlow. 1988. “The adenovirus E1A proteins bind to the retinoblastoma gene product.” in Current Communications in Molecular Biology, Cell Cycle Control in Eukaryotes, ed. D. Beach, C. Basilico, and J. Newport. Cold Spring Harbor Press, pp. 31-37.

Dyson N, Duffy LA, and E Harlow. 1988. “In vitro assays to detect the interaction of DNA tumor virus transforming proteins with the retinoblastoma protein.” in Cancer Cells, vol. 7, The Molecular Diagnostics of Human Cancer, M. Furth and M. Greaves, eds. Cold Spring Harbor Press, pp. 235-240.

1987

Stephens C, Harlow E. “Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins.” EMBO J. 1987 Jul;6(7):2027-35. PMID: 2958276

Whyte P, and E Harlow. 1987. “Regions of the adenovirus E1A proteins that are required for transformation are binding sites for cellular proteins.” in Current communications in molecular biology, Nuclear oncogenes, ed. F. Alt, E. Harlow, and E. Ziff. Cold Spring Harbor Press, pp. 106-111.

1986

Pallas DC, Schley C, Mahoney M, Harlow E, Schaffhausen BS, Roberts TM. “Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production.” J Virol. 1986 Dec;60(3):1075-84. PMID: 3023660

Stephens C, and E Harlow. 1986. "Heterogeneity of adenovirus E1A proteins is due to post-translational modification of the primary translation products of the 12S and 13S mRNAs." in Cancer Cells, vol 4. DNA Tumor Viruses. M. Botchan and T. Grodzicker, ed. Cold Spring Harbor Laboratory Press. pp. 429-434.

Harlow E, Whyte P, Franza BR Jr, Schley C. “Association of adenovirus early-region 1A proteins with cellular polypeptides.” Mol Cell Biol. 1986 May;6(5):1579-89. PMID: 2431282

1985

Harlow E, Franza BR Jr, Schley C. “Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products.” J Virol. 1985 Sep;55(3):533-46. PMID: 3894685

Harlow E, Williamson NM, Ralston R, Helfman DM, Adams TE. “Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.” Mol Cell Biol. 1985 Jul;5(7):1601-10. PMID: 3894933

1984

Gooding L, Geib R, O'Connell K, and E Harlow. 1984. "Antibody and cellular detection of SV40 T-antigenic determinants on the surface of transformed cells." In Cancer Cells, vol 1. The Transformed Cell, A. Levine, G. Van de Woude, W. Topp, and J. Watson, ed. Cold Spring Harbor Press.

Benchimol S, Jenkins J, Crawford L, Leppard K, Lamb P, Williamson N, Pim D, and E Harlow. 1984. "Molecular analysis of the gene for the cellular tumor antigen p53." in Cancer Cells, vol 2. Oncogenes and Viral Proteins, G. Van de Woude, A. Levine, W. Topp, and J. Watson, ed. Cold Spring Harbor Press.

1983

Leppard K, Totty N, Waterfield M, Harlow E, Jenkins J, Crawford L. “Purification and partial amino acid sequence analysis of the cellular tumour antigen, p53, from mouse SV40-transformed cells.” EMBO J. 1983;2(11):1993-9. PMID: 6315411

Crawford L, Leppard K, Lane D, and E Harlow. 1983. "Cross reactions between
cellular proteins and SV40 T-antigen. in Tumor Viruses and Differentiation", E. Scolnick
and A. Levine, ed.

1982

Lane D, Harlow E. “Two different viral transforming proteins bind the same host tumour antigen.” Nature. 1982 Aug 5;298(5874):517. No abstract available. PMID: 7048105

Crawford L, Leppard K, Lane D, Harlow E. “Cellular proteins reactive with monoclonal antibodies directed against simian virus 40 T-antigen.” J Virol. 1982 May;42(2):612-20. PMID: 6177872

Crawford L, Harlow E. “Uniform nomenclature for monoclonal antibodies directed against virus-coded proteins of simian virus 40 and polyoma virus.” J Virol. 1982 Feb;41(2):709. PMID: 6281480

1981

Harlow E, Crawford LV, Pim DC, Williamson NM .“Monoclonal antibodies specific for simian virus 40 tumor antigens.” J Virol. 1981 Sep;39(3):861-9. PMID: 6169844

McCormick F, Clark R, Harlow E, Tjian R. “SV40 T antigen binds specifically to a cellular 53 K protein in vitro.” Nature. 1981 Jul 2;292(5818):63-5. PMID: 6268984

Harlow E, Pim DC, Crawford LV. “Complex of simian virus 40 large-T antigen and host 53,000-molecular-weight protein in monkey cells.” J Virol. 1981 Feb;37(2):564-73. PMID: 6163871

1980

McCormick F, Harlow E. “Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells.” J Virol. 1980 Apr;34(1):213-24. PMID: 6246255

Crawford L, Lane D, Denhardt D, Harlow E, Nicklin P, Osborn K, and D Pim. 1980.
"Characterization of the complex between SV40 large-T antigen and the 53K host protein
in transformed mouse cells." Cold Spring Harbor Symposium on Quantitative Biology
44:179-188.

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